We found a wide range of effects, which depend in a nonlinear and nonseparable manner on the spatial frequency, contrast, and spatial location of both stimulus and mask. Here, we investigated this issue by measuring, in human subjects (three males), the suppressive effect of static masks on the ocular following responses induced by moving stimuli. The interactions between preferred and suppressive stimuli are often quite complex and vary across neurons, even within a single area, making it difficult to infer their collective effect on behavioral responses mediated by activity across populations of neurons. Usually, they are also suppressed by another set of stimuli that have little effect when presented in isolation. Sensory neurons are activated by a range of stimuli to which they are said to be tuned. We conclude that the ocular following system is well developed by age six, and OFRs can be recorded non-invasively in young children in a clinical setting. A power analysis indicates that even considerably smaller movements could be detected. Across subjects, we observed a large variability in the magnitude of the movements (by a factor of 4) OFR magnitude was however not correlated with age. With the developed system we were able to non-invasively detect OFRs in all children in short recording sessions. The OFRs were acquired non-invasively by a custom developed high-resolution video-oculography system, described in this study. We recorded ocular following responses (OFRs)–defined as the change in eye position in the 80–160 ms time window following the motion onset of a large textured stimulus–in 14 school-age children (6 to 13 years old, 9 males and 5 females), under recording conditions that closely mimic a clinical setting. Notably, they have so far only been recorded in adults.
Their translation from research to clinical setting has however been hindered by their small size, which makes them difficult to record, and by a lack of data about their properties in sizable populations.
Recently, it has been shown that they also reliably reveal stereoanomalies, and, thus, might have clinical applications. Ocular following eye movements have provided insights into how the visual system of humans and monkeys processes motion.
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